Method for screening the receptor-ligand binding in live cell
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United States of America Patent
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Sep 28, 2010
Grant Date -
Aug 6, 2009
app pub date -
Apr 29, 2007
filing date -
Apr 29, 2006
priority date (Note) -
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Abstract
The invention relates to methods and system for detecting ligand binding to membrane receptors and endocytosis. A method for detecting ligand binding to a membrane receptor includes the steps of: incubating the cell with a dye and a ligand; and detecting dye-containing endocytic vesicles in the cell. A system for screening ligand binding to membrane receptors includes an automatic liquid handling device; an x-y stage for positioning a plate; a microscope configured to image endocytic vesicles of a cell; a software for automatic analysis of FM spots (endocytic vesicles); and a control unit configured to control the movement of the x-y stage and the microscope.
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