Heteroaromatic compounds as inhibitors of stearoyl-coenzyme a delta-9 desaturase

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United States of America Patent

PATENT NO 7799787
APP PUB NO 20090088431A1
SERIAL NO

12086023

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Heteroaromatic compounds of structural formula (I) are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; lipid disorders; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; fatty liver disease and cancer.

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Patent Owner(s)

Patent OwnerAddress
MERCK FROSST CANADA LTD16711 TRANS-CANADA HWY KIRKLAND QUEBEC H9H 3L1

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Deschenes, Denis Dorval, CA 17 123
Fortin, Rejean Montreal, CA 39 559
Li, Chun Sing Dollard-des-Ormeaux, CA 43 246
Oballa, Renata M Kirkland, CA 5 60
Ramtohul, Yeeman K Pierrefonds, CA 25 101

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