Acyl pseudodipeptides which carry a functionalised auxialiary arm
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United States of America Patent
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Sep 21, 2010
Grant Date -
Oct 30, 2003
app pub date -
Dec 21, 2000
filing date -
Dec 22, 1999
priority date (Note) -
Expired
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Abstract
The present invention is directed in particular to dipeptide-like compounds derived from functionally substituted amino acids, having fatty acid chains bound thereto through amidification of the amine functional groups of said dipeptide-like compounds, one end portion of which bears an accessory functional side chain spacer, with the other end portion being an acid group either in neutral or charged state.Compounds of the present invention have immunomodulating properties like adjuvants, In addition, compounds of the invention can be grafted on a given antigen in order to modulate or tune the immune response or can be equally grafted on a pharmaceutical carrier to enhance the therapeutic effect or targeting thereof. Accordingly, compounds of the invention find use in human and veterinary medicine both as immunogens and diagnostic tools.
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