Transgenic mice expressing antibodies specific for genes of interest and uses thereof

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United States of America Patent

PATENT NO 7795494
APP PUB NO 20020138857A1
SERIAL NO

10104148

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Abstract

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The invention provides compositions and methods for the generation of novel non-human transgenic animals which contain an alteration in a gene of interest. These transgenic animals are capable of generating antibodies, e.g., human monoclonal antibodies, specific for the product of a gene of interest that has been functionally disrupted in the transgenic animal. Furthermore, the methods and compositions of the invention are suitable for use in the treatment, diagnosis, and imaging of disease.

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Patent Owner(s)

Patent OwnerAddress
ABBOTT GMBH & CO KGKNOLLSTRASSE LUDWIGSHAFEN LUDWIGSHAFEN

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ghayur, Tariq Holliston, US 128 4674

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