Methods of treatment of a bcl-2 disorder using bcl-2 antisense oligomers

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United States of America Patent

PATENT NO 7795232
SERIAL NO

09709170

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention is directed to the use of bcl-2 antisense oligomers to treat and prevent bcl-2 related disorders. These disorders include cancers, tumors, carcinomas and cell-proliferative related disorders. In one embodiment of the invention, a bcl-2 antisense oligomer is administered at high doses. The present invention is also directed to a method of preventing or treating a bcl-2 related disorder, in particular cancer, comprising administering a bcl-2 antisense oligomer for short periods of time. The present invention is further drawn to the use of bcl-2 antisense oligomers to increase the sensitivity of a subject to cancer therapeutics. The present invention also relates to pharmaceutical compositions comprising one or more bcl-2 antisense oligomers, which may comprise one or more cancer therapeutic agents.

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Patent Owner(s)

Patent OwnerAddress
GENTA INCORPORATED3550 GENERAL ATOMICS COURT SAN DIEGO CALIFORNIA 92121

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Fingert, Howard Berkeley Heights, US 2 0
Klem, Robert E Berkeley Heights, US 12 112
Warrell, Raymond P Berkeley Heights, US 8 7

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