Methods and compounds for inhibiting amyloid deposits
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United States of America Patent
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Aug 31, 2010
Grant Date -
Sep 18, 2008
app pub date -
May 22, 2008
filing date -
May 24, 1999
priority date (Note) -
Expired
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Abstract
Methods and compositions which are useful in the treatment of amyloidosis. In particular, methods and compositions are provided for inhibiting, preventing and treating amyloid deposition, e.g., in pancreatic islets, wherein the amyloidotic deposits are islet amyloid polypeptide (IAPP)-associated amyloid deposition or deposits. The methods of the invention involve administering to a subject a therapeutic compound which inhibits IAPP-associated amyloid deposits. Accordingly, the compositions and methods of the invention are useful for inhibiting IAPP-associated amyloidosis in disorders in which such amyloid deposition occurs, such as diabetes.
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