Thiadiazoles as CXC- and CC- chemokine receptor ligands

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United States of America Patent

PATENT NO 7786149
APP PUB NO 20080090823A1
SERIAL NO

11861870

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Disclosed are novel compounds of the formula:and the pharmaceutically acceptable salts and solvates thereof. Examples of groups comprising Substituent A include heteroaryl, aryl, heterocycloalkyl, cycloalkyl, aryl, alkynyl, alkenyl, aminoalkyl, alkyl or amino. Examples of groups comprising Substituent B include aryl and heteroaryl. Also disclosed is a method of treating a chemokine mediated diseases, such as, cancer, angiogenisis, angiogenic ocular diseases, pulmonary diseases, multiple sclerosis, rheumatoid arthritis, osteoarthritis, stroke and ischemia reperfusion injury, pain (e.g., acute pain, acute and chronic inflammatory pain, and neuropathic pain) using a compound of formula IA.

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Patent Owner(s)

Patent OwnerAddress
MERCK SHARP & DOHME CORP126 EAST LINCOLN AVENUE RAHWAY NJ 07065

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Aki, Cynthia J Livingston, US 17 344
Baldwin, John J Gwynedd Valley, US 214 2088
Biju, Purakkattle J Piscataway, US 16 305
Chao, Jianhua Pompton Lakes, US 46 481
Merritt, J Robert Ewing, US 17 349
Taveras, Arthur G Southborough, US 84 1161
Yu, Younong East Brunswick, US 57 593
Zheng, Junying Bridgewater, US 26 176

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