Fluoroalkoxycombretastatin derivatives, method for producing the same and use thereof
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United States of America Patent
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Aug 31, 2010
Grant Date -
Dec 11, 2008
app pub date -
Nov 22, 2006
filing date -
Jun 6, 2006
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Abstract
is alkyl with 1-8 carbon atoms and 1-17 fluorine atoms, R is amino, substituted amino, hydroxyl, nitro, halo, alkyloxy, phosphate or amino acid side chain. Said derivatives have a capability to inhibit the polymerization of microtubules and are useful in treatment against tumor and neovascularization.
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