Adenovirus E1B-55K single amino acid mutants and methods of use

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United States of America Patent

PATENT NO 7785887
SERIAL NO

10669768

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Abstract

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Adenoviral mutants are described that have single amino acid mutations in the E1B-55K protein which mutations effect the p53 binding/inactivation and the late functions of the E1B-55K protein in a manner that enhances the efficacy of such viruses for treating cancer when compared to adenoviral mutants that have the E1B-55K region deleted.

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Patent Owner(s)

Patent OwnerAddress
TOYOTA JIDOSHA KABUSHIKI KAISHA1 TOYOTA-CHO TOYOTA-SHI AICHI-KEN 471-8571

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hermiston, Terry Corte Madera, US 52 309
Nye, Julie Berkeley, US 4 20
Shen, Yuqiao Richmond, US 13 73

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