Conjugates comprising a biodegradable polymer and uses therefor
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United States of America Patent
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Aug 31, 2010
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app pub date -
Aug 20, 2004
filing date -
Feb 20, 2002
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Abstract
Biologically active agents covalently linked to a polymer. The polymer is preferably a biodegradable polymer are provided. The biologically active agent is preferably a protein, such as an extracellular soluble protein, e.g., an extracellular enzyme. The enzyme can be an apyrase, e.g., NTPDase. Conjugates of the invention can be used as therapeutics in subjects. For example, a conjugate comprising an apyrase can be used for treating and preventing thrombosis, atherosclerotic plaque complications and vascular disorders.
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