Use of a native epitope for selecting evolved binding members from a library of mutants of a protein capable of binding to said epitope
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United States of America Patent
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Aug 17, 2010
Grant Date -
May 22, 2003
app pub date -
Jun 28, 2002
filing date -
Dec 27, 1999
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Expired
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Abstract
The invention provides a method for selecting at least one member from a library of proteinaceous molecules by providing at least one cell and/or a functional equivalent thereof, with at least part of the library under conditions that allow binding of any such member to an epitope in and/or on the cells and/or the functional equivalent thereof, removing unbound proteinaceous molecules and selecting the at least one member, wherein the library includes at least one mutant of a proteinaceous molecule capable of binding to the epitope.
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