Stabilized aptamers to PSMA and their use as prostate cancer therapeutics
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United States of America Patent
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Aug 3, 2010
Grant Date -
Feb 22, 2007
app pub date -
Mar 7, 2006
filing date -
Jun 18, 2002
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Expired
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Abstract
The present invention provides stabilized, high affinity nucleic acid ligands to PSMA. Methods for the identification and preparation of novel, stable, high affinity ligands to PSMA using the SELEX™ method with 2′-O-methyl substituted nucleic acids, and cell surface SELEX™ are described herein. Also included are methods and compositions for the treatment and diagnosis of disease characterized by PSMA expression, using the described nucleic acid ligands.
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