Process for preparation of highly pure isotretinoin
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United States of America Patent
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Jul 27, 2010
Grant Date -
Aug 28, 2008
app pub date -
Feb 20, 2008
filing date -
Feb 20, 2007
priority date (Note) -
Expired
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Abstract
The present invention relates to a process for preparation of isotretinoin and more specifically, to a purification process for obtaining highly pure isotretinoin that is useful as a keratolytic agent, particularly useful for the treatment of acne. The process involves treating isotretinoin containing metal contamination and/or other impurities with a base in a suitable solvent to form a solution of isotretinoin, followed by adsorption, precipiation, and filtration or centrifugation.
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