N-glycosylated antibody
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United States of America Patent
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Jul 20, 2010
Grant Date -
Apr 24, 2008
app pub date -
Jul 14, 2004
filing date -
Jul 14, 2004
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Abstract
The invention relates to a monoclonal antibody, or fragment of the antibody, that is derived from a parental monoclonal antibody, that recognizes the Lewis Y antigen, characterized in that the Fc region of the antibody, or fragment of the antibody, carries a bi-sected hybrid type N-glycosylation pattern and that the antibody shows at least 10 fold increased ADCC and at least 10% reduced CDC activity.
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