Methods for preparing biodegradable microparticle formulations containing pharmaceutically active agents
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United States of America Patent
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Jul 20, 2010
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Mar 8, 2007
app pub date -
Sep 7, 2005
filing date -
Sep 7, 2005
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Abstract
This invention is directed to an apparatus and method for producing microparticles comprising pharmacologically active agents and biodegradable polymers. The apparatus includes a spinning disk containing a reservoir in the center thereof and a flat inclined surface. The apparatus optionally includes serrations and/or a flat surface beneath the periphery of the disk that is parallel to the rotational axis of the disk. The invention is also directed to a method for producing microparticles containing pharmacologically active agents, using the spinning disk apparatus. Formulations containing ophthalmically active agents are provided. Formulations exhibiting zero order release rates are also described.
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