Azacyclopentane derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
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United States of America Patent
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Jul 13, 2010
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Apr 9, 2009
app pub date -
Jun 8, 2007
filing date -
Jun 13, 2006
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Abstract
Azacyclopentane derivatives of structural formula (I) are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease; atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; liver steatosis; and non-alcoholic steatohepatitis.
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