Poly(ADP-ribose) polymerase-gene
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United States of America Patent
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Jul 13, 2010
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N/A
app pub date -
Jun 4, 1999
filing date -
Jun 5, 1998
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Abstract
The invention relates to poly(ADP-ribose)polymerase (PARP) homologs which have an amino acid sequence which has a) a functional NAD.sup.+ binding domain and b) no zinc finger sequence motif of the general formula CX.sub.2CX.sub.mHX.sub.2C in which m is an integral value from 28 or 30, and the X radicals are, independently of one another, any amino acid; and the functional equivalents thereof; nucleic acids coding therefor; antibodies with specificity for the novel protein; pharmaceutical and gene therapy compositions which comprise products according to the invention; methods for the analytical determination of the proteins and nucleic acids according to the invention; methods for identifying effectors or binding partners of the proteins according to the invention; novel PARP effectors; and methods for determining the activity of such effectors.
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