Safe mutant viral vaccines
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United States of America Patent
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Jul 13, 2010
Grant Date -
Nov 20, 2008
app pub date -
Apr 4, 2008
filing date -
Jul 29, 2003
priority date (Note) -
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Abstract
The present invention provides safe vaccines and methods of preparing such vaccines. The vaccines of the present invention contain at least two live mutant viruses of the same family or nucleic acid molecules encoding such viruses, wherein each of the two viruses or the encoding nucleic acids contains a mutation that confers a desirable phenotype and the mutations in the viruses reside in the same genomic site such that the mutant viruses cannot recombine with each other to eliminate the mutations.
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