Immunotoxins directed against c-erbB-2(HER-2/neu) related surface antigens

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United States of America Patent

PATENT NO 7754211
APP PUB NO 20050163774A1
SERIAL NO

10964195

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Abstract

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Novel immunotoxins and methods of treating neoplastic diseases are provided. More specifically, immunotoxins comprised conjugation of a c-erbB-2 targeting moiety and a cell growth modulator are provided. These immunotoxins specifically and selectively kill tumor cells that over-express the c-erbB-2 protein. The novel immunotoxins would be useful in treating human mammary carcinomas, human ovarian carcinomas, lung carcinomas, gastric tumors, salivary gland adenocarcinomas, and colon adenocarcinomas.

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Patent Owner(s)

Patent OwnerAddress
RESEARCH DEVELOPMENT FOUNDATION402 NORTH DIVISION STREET CARSON CITY NV 89703

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Rosenblum, Michael Sugar Land, US 14 133
Shawver, Laura K San Francisco, US 9 297

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