Transgenic nonhuman mammal representing the pathologic conditions of human rheumatoid arthritis
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United States of America Patent
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Jun 29, 2010
Grant Date -
Aug 23, 2007
app pub date -
Mar 8, 2005
filing date -
Mar 9, 2004
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Abstract
It is intended to provide a transgenic nonhuman mammal well representing the pathologic conditions of human rheumatoid arthritis. A transgenic nonhuman mammal is obtained by transferring a foreign DNA, wherein a DNA selected from the group consisting of an MHC class II transcriptional activator gene, the activity domain of an MHC class II transcriptional activator gene and a variant of an MHC class II transcriptional activator gene is provided under the control of a type II collagen promoter, into a cell at the early stage of development.
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