Indene derivatives and process for the preparation thereof
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United States of America Patent
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Jun 29, 2010
Grant Date -
Sep 27, 2007
app pub date -
Apr 12, 2005
filing date -
Apr 13, 2004
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Expired
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Abstract
The inventive indene derivatives of formula (I) are capable of selectively modulating the activities of peroxisome proliferator activated receptors (PPARs), causing no adverse side effects, and thus, they are useful for the treatment and prevention of disorders modulated by PPARs, i.e., metabolic syndromes such as diabetes, obesity, arteriosclerosis, hyperlipidemia, hyperinsulinism and hypertension, inflammatory diseases such as osteoporosis, liver cirrhosis and asthma, and cancer.
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