Methods and compositions for diagnosing carcinomas
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United States of America Patent
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Jun 29, 2010
Grant Date -
Jul 22, 2004
app pub date -
Feb 13, 2004
filing date -
Feb 26, 1999
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Abstract
The invention is directed to compositions and methods for the detection of a malignant condition, and relates to the discovery of soluble forms of mesothelin polypeptides, including mesothelin related antigen (MRA). In particular the invention provides a nucleic acid sequence encoding MRA and an MRA variant. The invention also provides a method of screening for the presence of a malignant condition in a subject by detecting reactivity of an antibody specific for a mesothelin polypeptide with a molecule naturally occurring in soluble form in a sample from such a subject, and by hybridization screening using an MRA nucleotide sequence, as well as other related advantages.
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