Comparative genomic resequencing

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United States of America Patent

PATENT NO 7745118
APP PUB NO 20050260645A1
SERIAL NO

11101841

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Abstract

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The present invention is an improved method of resequencing DNA using microarrays to rapidly map and identify SNPs, deletions and amplification events present in the genome of an organism. The method is performed by hybridizing a reference and a test genome to two separate arrays with each array exhibiting a specific intensity pattern. The intensity differences between the reference and the test genome arrays are used to produce a mutation map. The mapped differences are resequenced on a set of resequencing arrays to identify specific genetic mutations.

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Patent Owner(s)

Patent OwnerAddress
ROCHE NIMBLEGEN INC500 S ROSA ROAD MADISON WI 53719

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Albert, Thomas Fitchburg, US 30 773
Green, Roland D Madison, US 7 144
Nuwaysir, Emile F Madison, US 5 27
Smith, Steve Fitchburg, US 104 1318

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