Long lasting anti-angiogenic peptides
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United States of America Patent
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Jun 22, 2010
Grant Date -
Jun 22, 2006
app pub date -
Feb 8, 2006
filing date -
May 17, 1999
priority date (Note) -
Expired
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Abstract
Modified anti-angiogenic peptides are disclosed. The modified peptides are capable of forming a peptidase stabilized anti-angiogenic peptide. The modified anti-angiogenic peptides, particularly modified kringle 5 peptides are capable of forming a conjugate with a blood protein. Conjugates are prepared from anti-angiogenic peptides, particularly kringle 5 peptides, by combining the peptide with a reactive functional group with a blood protein. The conjugates may be formed in vivo or ex vivo. The conjugates are administered to patients to provide an anti-angiogenic effect.
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