Agents and use thereof
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United States of America Patent
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Jun 22, 2010
Grant Date -
Aug 7, 2008
app pub date -
Dec 16, 2005
filing date -
Dec 22, 2004
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The present invention provides agents for inhibiting the proliferation of cancer cells, wherein the agent inhibits the biological activity of hCAP18/LL-37. In a preferred embodiment, the agent alters the transcription, translation and/or binding properties of hCAP18/LL-37. Preferably, the agent is selected from the group consisting of short interfering RNA (siRNA) molecules, antisense oligonucleotides and compounds with binding affinity for hCAP18/LL-37. The invention further provides methods for inhibiting the proliferation of cancer cells in a patient, as well as methods and kits for diagnosing cancer.
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