Substituted 5-membered ring compounds and their use

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United States of America Patent

PATENT NO 7728016
APP PUB NO 20060235058A1
SERIAL NO

10561969

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Abstract

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are as defined in the specification are inhibitors of HSP90 and therefore of use in the treatment of, for example, cancers, viral disease, inflammatory diseases such as rheumatoid arthritis, asthma, multiple sclerosis, Type I diabetes, lupus, psoriasis and inflammatory bowel disease; cystic fibrosis angiogenesis-related disease such as diabetic retinopathy, haemangiomas, and endometriosis; or for protection of normal cells against chemotherapy-induced toxicity; or diseases where failure to undergo apoptosis is an underlying factor, or protection from hypoxia-ischemic injury due to elevation of Hsp70 in the heart and brain; scrapie/CJD, Huntingdon's and Alzheimer's disease.

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Patent Owner(s)

Patent OwnerAddress
CANCER RESEARCH TECHNOLOGY LTDLONDON LONDON LONDON
INSTITUTE OF CANCER RESEARCH THE123 OLD BROMPTON ROAD LONDON SW7 3RP
VERNALIS (CAMBRIDGE) LIMITEDABINGTON CAMBRIDGE CB1 6GB

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cheung, Kwai Ming London, GB 12 108
Drysdale, Martin James Abington, GB 26 164
Dymock, Brian William Abingdon, GB 27 314
McDonald, Edward London, GB 42 424

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