Live genetically engineered protozoan vaccine
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United States of America Patent
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May 25, 2010
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app pub date -
Jun 22, 2005
filing date -
Dec 3, 2004
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Abstract
The invention provides methods for inducing an immune response in a vertebrate host against a protozoan parasite, comprising administering to the host a live protozoan parasite that is genetically engineered to disrupt a stage-specific gene function that is required by the protozoan parasite to establish a secondary infection in the vertebrate host. Representative protozoan parasites belong to the phyla Apicomplexa and Kinetoplastida. The vertebrate host may be a mammal or a bird.
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