Non-immunogenic, hydrophilic/cationic block copolymers and uses thereof

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United States of America Patent

PATENT NO 7718432
APP PUB NO 20070259828A1
SERIAL NO

11725964

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Abstract

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The present invention provides novel non-immunogenic, hydrophilic/cationic block copolymers comprising a neutral-hydrophilic polymer and a cationic polymer, wherein both polymers have well-defined chain-end functionality. A representative example of such a block copolymer comprises poly(N-(2-hydroxypropyl)methacrylamide) (PHPMA) and poly(N-[3-(dimethylamino)propyl]methacrylamide) (PDMAPMA). Also provided is a synthesis method thereof in aqueous media via reversible addition fragmentation chain transfer (RAFT) polymerization. Further provided are uses of these block copolymers as drug delivery vehicles and protection agents.

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Patent Owner(s)

Patent OwnerAddress
UNIVERSITY OF SOUTHERN MISSISSIPPI THE118 COLLEGE DRIVE #5116 HATTIESBURG MS 39406

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Huang, Faqing Hattiesburg, US 3 5
McCormick, Charles L Hattiesburg, US 14 178
Scales, Charles W San Ramon, US 28 511

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