AAV vector compositions and methods for enhanced expression of immunoglobulins using the same
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United States of America Patent
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May 11, 2010
Grant Date -
Feb 16, 2006
app pub date -
Jul 13, 2005
filing date -
Jul 13, 2004
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Expired
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Abstract
Single AAV vector constructs for expression of an immunoglobulin molecule or fragment thereof and methods of making and using the same are described. The AAV vectors comprise a self-processing cleavage sequence between a first and second immunoglobulin coding sequence allowing for expression of a functional antibody molecule using a single promoter. The vector constructs may further include an additional proteolytic cleavage sequence which provides a means to remove the self processing peptide sequence from an expressed immunoglobulin molecule or fragment thereof. The vector constructs find utility in enhanced production of biologically active immunoglobulins or fragments thereof in vitro and in vivo.
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