Methods and compositions for use in diagnosing and characterizing diseases involving abnormal apoptosis

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 7713515
APP PUB NO 20050019756A1
SERIAL NO

10855879

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Abstract

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Methods are provided for diagnosing and/or characterizing disease involving abnormal levels of cellular apoptosis activity in a subject. In the subject methods, a sample is obtained from a subject suspected of having or known to have a disease involving abnormal levels of cellular apoptosis. The sample is then assayed for the presence of low molecular weight Actin protein fragments. The assay results are used to diagnose the presence of disease involving abnormal levels of cellular apoptosis activity and/or characterize disease involving abnormal levels of cellular apoptosis activity in the subject, e.g. to confirm an initial disease involving abnormal levels of cellular apoptosis diagnosis, to determine the stage of the disease, to monitor disease progression, to predict disease attacks, and the like. Also provided by the subject invention are kits for practicing the methods.

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Patent Owner(s)

Patent OwnerAddress
PROTEA BIOPHARMA N VDE TYRASLAAN 111 NEDER-OVER-HEEMBEEK B-1120

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
De, Meirleir Kenny Mechelen, BE 7 4
Englebienne, Patrick Zingem, BE 18 47
Herst, Charles Vincent Oakland, US 5 7

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