Prodrugs built as multiple self-elimination-release spacers
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United States of America Patent
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Apr 27, 2010
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app pub date -
Nov 14, 2003
filing date -
Nov 14, 2002
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Abstract
This invention concerns multiple release spacers and spacer systems, which release multiple leaving groups following a single activation. It concerns compounds comprising a specifier linked to two or more of the same or different leaving groups (L in the figure) via a self-eliminating multiple release spacer or spacer system, which compounds upon a single activation step, in particular removal or transformation of the specifier, release at least two leaving groups.
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