Regulation of food intake by modulation of long-chain fatty acyl-CoA levels in the hypothalamus
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Apr 27, 2010
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app pub date -
Feb 12, 2004
filing date -
Feb 13, 2003
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Abstract
Methods of reducing food intake and glucose production in a mammal, or restoring hepatic autoregulation are provided. The methods involve increasing long-chain fatty acyl-Co-A (LC-CoA) levels in the hypothalamus, or stimulating efferent fibers in the hepatic branch of the vagus nerve. Also provided are methods of increasing food intake and glucose production in a mammal. The methods involve decreasing long-chain fatty acyl-Co-A (LC-CoA) levels in the hypothalamus of the mammal.
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