Method for screening therapeutic agents for disuse muscular atrophy using interaction between selected proteins and a polyubiquitin chain
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United States of America Patent
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Apr 20, 2010
Grant Date -
Sep 18, 2008
app pub date -
Dec 7, 2004
filing date -
Dec 8, 2003
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Expired
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Abstract
A method for screening therapeutic agents for disuse muscular atrophy is provided that includes the steps of interacting a selected protein with a polyubiquitin chain in the presence of a candidate therapeutic agent, and determining the effect of the candidate on the binding strength between the protein and the polyubiquitin chain. The effect may be observed by color development on a substrate when the steps are carried out by way of an enzyme-linked immunosorbent assay, or by direct observation via NMR spectroscopy, X-ray crystal analysis, electron microscopy or surface plasmon resonance.
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