Methods for making simvastatin and intermediates
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United States of America Patent
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Apr 20, 2010
Grant Date -
Jul 31, 2008
app pub date -
Oct 20, 2004
filing date -
Oct 21, 2003
priority date (Note) -
Expired
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Abstract
The invention provides synthetic chemical and chemoenzymatic methods of producing simvastatin and various intermediates. In one aspect, enzymes such as hydrolases, e.g., esterases, are used in the methods of the invention.
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