Tocopherol derivatives with a long hydroxylated chain, which can be used as neurotrophics
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United States of America Patent
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Apr 6, 2010
Grant Date -
May 10, 2007
app pub date -
Sep 24, 2004
filing date -
Sep 26, 2003
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Expired
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Abstract
The invention relates to any isolated or synthetic compound and, in particular, to compounds having formula which can: modulate the cell specification of neural stem cells, promote the differentiation and subsequent survival of differentiating glial cells and neurones, and promote the differentiation of oligodendrocyte precursor cells into mature oligodendrocytes. In addition, the inventive compounds can reduce the inflammatory component of diseases that affect the nervous system, for example, by reducing activation of the microglia an/or astrocytes and/or by reducing reactive gliosis. The invention also relates to the methods of preparing such compounds and to the use of same in the preparation of a pharmaceutical composition that is intended for the prevention or treatment of diseases that affect the nervous system. More specifically, the inventive compounds have general formula.
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