Thiadiazoledioxides and thiadiazoleoxides as CXC- and CC-chemokine receptor ligands
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United States of America Patent
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Apr 6, 2010
Grant Date -
Nov 15, 2007
app pub date -
Jan 9, 2007
filing date -
Oct 9, 2002
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Expired
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Abstract
Disclosed are novel compounds of the formula:and the pharmaceutically acceptable salts and solvates thereof. Examples of groups comprising Substituent A include heteroaryl, aryl, heterocycloalkyl, cycloalkyl, aryl, alkynyl, alkenyl, aminoalkyl, alkyl or amino. Examples of groups comprising Substituent B include aryl and heteroaryl. Also disclosed is a method of treating a chemokine mediated diseases, such as, cancer, angiogenisis, angiogenic ocular diseases, pulmonary diseases, multiple sclerosis, rheumatoid arthritis, osteoarthritis, stroke and cardiac reperfusion injury, acute pain, acute and chronic inflammatory pain, and neuropathic pain using a compound of formula IA.
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