Process for oseltamivir phosphate
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United States of America Patent
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Mar 30, 2010
Grant Date -
Feb 26, 2009
app pub date -
Nov 25, 2005
filing date -
Nov 25, 2005
priority date (Note) -
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Abstract
The present invention provides an improved and commercially viable process for the preparation of oseltamivir phosphate. Thus, for example, ethyl (3R,4R,5S)-4-amino-5-azido-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate is acetylated with acetic anhydride in methylene chloride in the presence of triethyl amine in the absence of water to give ethyl (3R,4R,5S)-4-(acetylamino)-5-azido-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate.
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