Pegylated factor VIII
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United States of America Patent
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Mar 23, 2010
Grant Date -
Oct 18, 2007
app pub date -
Mar 29, 2007
filing date -
Mar 31, 2006
priority date (Note) -
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Abstract
The invention is a proteinaceous construct comprising a Factor VIII molecule having at least a portion of the B domain intact, which is conjugated to a water-soluble polymer such as polyethylene glycol having a molecular weight of greater than 10,000 Daltons. The construct has a biological activity of at least 80% of the biological activity of native Factor VIII, and the in vivo half-life of the construct is increased by at least 1.5 fold as compared to the in vivo half-life of native factor FVIII.
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