Nitroheteroaryl-containing rifamycin derivatives
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United States of America Patent
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Mar 16, 2010
Grant Date -
Jun 12, 2008
app pub date -
Jul 12, 2007
filing date -
Jul 12, 2006
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Abstract
Substituted rifamycin derivatives in which a nitroimidazole, nitrothiazole or nitrofuran pharmacophore is covalently bonded to a rifamycin, methods of using the rifamycin derivatives, and pharmaceutical compositions containing the rifamycin derivatives are disclosed. Methods of synthesizing these substituted rifamycin derivatives are also disclosed. The rifamycin derivatives possess antibacterial activity, and are effective against a number of human and veterinary pathogens in the treatment of bacterial diseases.
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