Compositions and methods for siRNA inhibition of angiogenesis
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United States of America Patent
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Mar 9, 2010
Grant Date -
Jun 28, 2007
app pub date -
Sep 8, 2006
filing date -
Jul 24, 2002
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Abstract
RNA interference using small interfering RNAs which are specific for the vascular endothelial growth factor (VEGF) gene and the VEGF receptor genes Flt-1 and Flk-1/KDR inhibit expression of these genes. Diseases which involve angiogenesis stimulated by overexpression of VEGF, such as diabetic retinopathy, age related macular degeneration and many types of cancer, can be treated by administering the small interfering RNAs.
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