Bicyclic nitroimidazole-substituted phenyl oxazolidinones
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United States of America Patent
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Feb 23, 2010
Grant Date -
Nov 12, 2009
app pub date -
Mar 25, 2009
filing date -
Mar 26, 2008
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Abstract
The current invention provides a series of bicyclic nitroimidazole-substituted phenyl oxazolidinones in which a bicyclic nitroimidazole pharmacophore is covalently bonded to a phenyl oxazolidinone, their pharmaceutical compositions, and the method of use of the compositions for prevention and treatment of bacterial infections. The bicyclic nitroimidazole-substituted phenyl oxazolidinones possess surprising antibacterial activity against wild-type and resistant strains of pathogens, and are therefore useful for the prevention, control and treatment of a number of human and veterinary bacterial infections caused by these pathogens, such as Mycobacterium tuberculosis.
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