Selective high affinity polydentate ligands and methods of making such
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United States of America Patent
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Feb 16, 2010
Grant Date -
Apr 20, 2006
app pub date -
Feb 9, 2005
filing date -
Feb 9, 2004
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Abstract
This invention provides novel polydentate selective high affinity ligands (SHALs) that can be used in a variety of applications in a manner analogous to the use of antibodies. SHALs typically comprise a multiplicity of ligands that each bind different region son the target molecule. The ligands are joined directly or through a linker thereby forming a polydentate moiety that typically binds the target molecule with high selectivity and avidity.
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