Natriuretic compounds, conjugates, and uses thereof
Number of patents in Portfolio can not be more than 2000
United States of America Patent
Stats
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Feb 16, 2010
Grant Date -
Oct 14, 2004
app pub date -
Nov 26, 2003
filing date -
Nov 26, 2002
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Modified natriuretic compounds and conjugates thereof are disclosed in the present invention. In particular, conjugated forms of hBNP are provided that include at least one modifying moiety attached thereto. The modified natriuretic compound conjugates retain activity for stimulating cGMP production, binding to NPR-A receptor, and in some embodiments an improved half-life in circulation as compared to unmodified counterpart natriuretic compounds. Oral, parenteral, subcutaneous, and intravenous forms of the compounds and conjugates may be prepared as treatments and/or therapies for heart conditions particularly congestive heart failure. Modifying moieties comprising oligomeric structures having a variety of lengths and configurations are also disclosed. Analogs of the natriuretic compound are also disclosed, having an amino acid sequence that is other than the native sequence.
First Claim
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Family

- 15 United States
- 10 France
- 8 Japan
- 7 China
- 5 Korea
- 2 Other
Patent Owner(s)
Patent Owner | Address | |
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BIOCON LIMITED | KARNATAKA BANGALORE 560 100 |
International Classification(s)
Inventor(s)
Inventor Name | Address | # of filed Patents | Total Citations |
---|---|---|---|
Ekwuribe, Nnochiri N | Cary, US | 63 | 1265 |
# of filed Patents : 63 Total Citations : 1265 | |||
James, Kenneth D | Mebane, US | 13 | 325 |
# of filed Patents : 13 Total Citations : 325 | |||
Malkar, Navdeep B | Cary, US | 16 | 277 |
# of filed Patents : 16 Total Citations : 277 | |||
Miller, Mark A | Raleigh, US | 248 | 4871 |
# of filed Patents : 248 Total Citations : 4871 | |||
Radhakrishnan, Balasingam | Chapel Hill, US | 43 | 487 |
# of filed Patents : 43 Total Citations : 487 |
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Maintenance Fees
Fee | Large entity fee | small entity fee | micro entity fee | due date |
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Fee | Large entity fee | small entity fee | micro entity fee |
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Surcharge after expiration - Late payment is unavoidable | $700.00 | $350.00 | $175.00 |
Surcharge after expiration - Late payment is unintentional | $1,640.00 | $820.00 | $410.00 |
Full Text

Legal Events
Date | Code | Event | Description |
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Oct 13, 2014 | STCH | INFORMATION ON STATUS: PATENT DISCONTINUATION | free format text: PATENT EXPIRED DUE TO NONPAYMENT OF MAINTENANCE FEES UNDER 37 CFR 1.362 |
Sep 17, 2014 | FP | LAPSED DUE TO FAILURE TO PAY MAINTENANCE FEE | Effective Date: Sep 17, 2014 |
Sep 17, 2014 | LAPS | LAPSE FOR FAILURE TO PAY MAINTENANCE FEES | |
Apr 25, 2014 | REMI | MAINTENANCE FEE REMINDER MAILED | |
Feb 18, 2010 | FPAY | FEE PAYMENT | year of fee payment: 8 |
Dec 02, 2009 | FEPP | FEE PAYMENT PROCEDURE | free format text: PAYOR NUMBER ASSIGNED (ORIGINAL EVENT CODE: ASPN); ENTITY STATUS OF PATENT OWNER: LARGE ENTITY |
Feb 23, 2006 | FPAY | FEE PAYMENT | year of fee payment: 4 |
Sep 17, 2002 | I | Issuance | |
Jun 27, 2000 | F | Filing | |
Jun 13, 2000 | AS | ASSIGNMENT | free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:GANTER, CHRISTIAN;REEL/FRAME:010900/0960 Owner name: GRAPHA-HOLDING AG, SWITZERLAND Effective Date: Jun 13, 2000 |
Jul 22, 1999 | PD | Priority Date |

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