Approaches to identify less harmful tobacco and tobacco products
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United States of America Patent
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Feb 16, 2010
Grant Date -
Sep 18, 2008
app pub date -
May 11, 2005
filing date -
May 12, 2004
priority date (Note) -
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Abstract
Aspects of the invention concern methods for detecting, identifying and evaluating tobacco and tobacco products to determine the potential that these compositions have to contribute to a tobacco-related disease. It is based, at least in part; on the discovery that exposure of pulmonary cells to smoke or smoke condensate obtained from tobacco or tobacco products induces double stranded breaks in cellular DNA, which were efficiently detected using assays that measure the presence, absence, or amount of phosphorylation of the histone, H2AX.
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