Low-toxicity, long-circulating human interferon-alpha PEGylated mutants
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United States of America Patent
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Feb 16, 2010
Grant Date -
Jan 11, 2007
app pub date -
Jun 20, 2006
filing date -
Jun 20, 2005
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Abstract
Interferon-alpha (IFNα) analog proteins modified by chemical attachment of at least one hydrophilic polymer moiety, such as polyethylene glycol chain, are described. In one embodiment, the IFNα analog protein has an amino acid sequence that differs from a native human IFNα interferon-alpha by one or more amino acid residues in the N-terminal region, comprised of between about residues 1-27, inclusive, by one or more substitutions selected based on the amino acid residue at the corresponding position of a mature interferon-tau (IFNτ) protein. Methods of treating viral diseases and other disorders with the polymer-modified IFNα analog protein are also described.
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