Process for the preparation of insulin or an insulin derivative in the presence of oxygen
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United States of America Patent
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Feb 9, 2010
Grant Date -
May 10, 2007
app pub date -
Oct 2, 2006
filing date -
Apr 1, 2004
priority date (Note) -
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Abstract
The present invention comprises a process for preparing insulin or an insulin derivative with correctly linked cysteine bridges from a precursor of said insulin or insulin derivative, wherein said precursor is subjected to a folding process in the presence of cysteine or cysteine hydrochloride and a chaotropic auxiliary compound. The insulin or insulin derivative with correctly linked cysteine bridges is obtained by enzymic cleavage by means of trypsin or a trypsin-like enzyme and, where appropriate, additionally by means of carboxypeptidase B and subsequent purification on an adsorber resin, which process is carried out at varied pH and temperature ranges.
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