Membrane-permeable NFAT inhibitory peptide
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United States of America Patent
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Feb 9, 2010
Grant Date -
Apr 26, 2007
app pub date -
Dec 5, 2006
filing date -
Feb 28, 2002
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Expired
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Abstract
The present invention aims to solve the conventional problems by providing a peptide compound, in which when administered to a patient of immunologic disease, cardiac hypertrophy or a disease caused by NFAT activation, the period from administration to actual exhibition of effectiveness is short and there are no side effects or antigenicity. Specifically, the present invention relates to a membrane permeable NFAT inhibitory peptide comprising several consecutive arginines and a NFAT-activity inhibitory peptide sequence; a NFAT activation inhibitory agent comprising the peptide; and a immunosuppressive agent and cardiac hypertrophy suppressive agent, comprising the peptide compound as the active ingredient.
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