Methods utilizing target genes related to immune-mediated diseases
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United States of America Patent
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Feb 9, 2010
Grant Date -
Dec 14, 2006
app pub date -
Mar 17, 2004
filing date -
Mar 17, 2003
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Abstract
The present invention provides methods utilizing novel target genes related to immune-mediated diseases, such as asthma, allergy and autoimmune diseases. The invention is based on a molecular level description of the polarization of CD4+ precursor cells (Thp) from which T helper cells are known to originate. Particularly, the present invention provides a method of identifying a compound capable of modulating the polarization of CD4+ lymphocytes. The invention is also related to a method for assessing the presence of, or a predisposition to, an immune-related disorder in a subject.
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