Binding of pathological forms of prion proteins
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United States of America Patent
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Feb 9, 2010
Grant Date -
Oct 6, 2005
app pub date -
Feb 28, 2003
filing date -
Feb 28, 2002
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Abstract
Infective aggregating forms of proteins such as PrP, amyloid, and tau are bound selectively in the presence of the normal form protein using a polyionic binding agent such as dextran sulphate or pentosan (anionic), or polyamine compounds such as pDADMAC (cationic) under selective binding conditions including the use of n-lauroylsarcosine at mildly alkaline pH, and may then be assayed.
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