Crystallized structure of estrogen related receptor gamma in complex with bisphenol A
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United States of America Patent
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Feb 2, 2010
Grant Date -
Nov 30, 2006
app pub date -
May 26, 2006
filing date -
May 27, 2005
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Abstract
A method for the identification of novel compounds that interact and stabilize the ligand binding domain of estrogen-related receptor gamma (ERRγ), a methodology for producing diffraction quality crystal structures in the presence of antagonist and agonist ligands, including Bisphenol A, and the identification of novel biologically-active compounds that have an effect on the transcriptional-activating activity of ERRγ are disclosed.
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